Studies of the influence of different cross-linking reagents on the immune response against a B-epitope. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bioconjugate Chemistry Année : 1992

Studies of the influence of different cross-linking reagents on the immune response against a B-epitope.

Résumé

We have previously shown that the carrier polytuftsin obtained by polycondensation of tuftsin, a naturally occurring macrophage activator, increases significantly the antibody response against a linked B-epitope. In the present work, we have studied the influence of different cross-linking reagents on the quality of the conjugation and on the immune response, at both B-cell and T-cell levels. We observed that the cross-linking method used for coupling the B-epitope to the carrier influences the immune response. A hypothesis is put forward to explain the differences observed.

Dates et versions

hal-02146933 , version 1 (04-06-2019)

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A. Delmas, A. Brack, Y. Trudelle. Studies of the influence of different cross-linking reagents on the immune response against a B-epitope.. Bioconjugate Chemistry, 1992, 3 (1), pp.80-4. ⟨10.1021/bc00013a013⟩. ⟨hal-02146933⟩
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