Journal Articles FEBS Letters Year : 1994

Influence of the conformation of a macromolecule on the generation of T-cell proliferative response. A study with model polypeptides.

Abstract

To study the influence of the conformation of polypeptidic macromolecules on the generation of T-cell epitopes, sequential polypeptides with an octamer repeat unit were designed and synthesized. They adopt mainly unordered and alpha-helical conformations. Among these polypeptides, those containing proline are fully or partly unordered, and are more effective at inducing T-cell proliferation than a proline-free very stable alpha-helical polypeptide. This extremely stable alpha-helical conformation, probably stabilized by aggregation, would enhance its stability against proteolytic processing.

No file

Dates and versions

hal-02146930 , version 1 (04-06-2019)

Identifiers

  • HAL Id : hal-02146930 , version 1
  • PUBMED : 7519569

Cite

E Lacassie, A. Delmas, Y. Trudelle. Influence of the conformation of a macromolecule on the generation of T-cell proliferative response. A study with model polypeptides.. FEBS Letters, 1994, 349 (3), pp.380-4. ⟨hal-02146930⟩
43 View
0 Download

Altmetric

Share

  • More