RADX Modulates RAD51 Activity to Control Replication Fork Protection
Résumé
Graphical Abstract Highlights d RADX loss prevents fork degradation when RAD51 function is compromised d RADX inactivation prevents both MRE11-and DNA2-dependent fork degradation d Fork protection requires higher cellular levels of RAD51 than fork reversal d RADX antagonizes RAD51 DNA binding and displaces pre-bound RAD51 from ssDNA In Brief Bhat et al. discover that RADX competes with RAD51 for ssDNA and silencing RADX confers fork protection to cells with compromised RAD51 filament stability caused by loss of BRCA1, BOD1L, and the Fanconi anemia pathway. In addition, they find that more RAD51 is needed for fork stabilization than fork reversal.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers éditeurs autorisés sur une archive ouverte
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