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Communication Dans Un Congrès Année : 2018

From experimental data to a numerical model of Keloid-Skin Composite structure

Résumé

As keloids are a consequence of abnormal wound healing process, the fibroblast proliferate excessively in dermis (Ogawa & Orgill, Mechanobiology of Cutaneous Wound Healing and Scarring, in Bioengineering Research of Chronic Wounds, 2009) and develop an unsightly and uncomfortable tumor that replaces the healthy skin. The structure and the properties of keloids highly differe from healthy skin, in particular the mechanical properties. Several anatomic sites are known as pro-keloid sites. Others don’t develop any keloid (Ogawa & Orgill, Mechanobiology of Cutaneous Wound Healing and Scarring, in Bioengineering Research of Chronic Wounds, 2009). In addition to genetic and biological causes, the mechanical solicitation of the in vivo skin induces the growth of keloid. Furthermore, this is highly related to the site and the range of body motion. This assumption is well documented by (Ogawa, et al., 2012). The design of a medical device should improve the prevention of the pathology but the mechanical components of the stress fields have to be determine in order to explain the mechanical process of keloid growth.
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Dates et versions

hal-02131357 , version 1 (16-05-2019)

Identifiants

  • HAL Id : hal-02131357 , version 1

Citer

Danas Sutula, Marco Sensale, Jérôme Chambert, Franz Chouly, Arnaud Lejeune, et al.. From experimental data to a numerical model of Keloid-Skin Composite structure. International Keloid Symposium, Jun 2018, Rome, Italy. ⟨hal-02131357⟩
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