Tax Protein-induced Expression of Antiapoptotic Bfl-1 Protein Contributes to Survival of Human T-cell Leukemia Virus Type 1 (HTLV-1)-infected T-cells
Résumé
Background: Antiapoptotic Bcl-2 proteins are up-regulated in HTLV-1-infected T-cells.
Results: Antiapoptotic Bfl-1 protein is regulated by viral Tax and HBZ proteins and is involved in survival of HTLV-1-transformed T-cells.
Conclusion: Bfl-1, as well as Bcl-xL, induces resistance to apoptosis in HTLV-1-transformed T-cells.
Significance: We provide evidence for Bfl-1 and Bcl-xL as potential therapeutic targets in the treatment of leukemia/lymphoma associated with HTLV-1.
Domaines
Virologie
Origine : Fichiers éditeurs autorisés sur une archive ouverte