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Article Dans Une Revue Immunity Année : 2018

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Sandrine Henri
Clare Pridans
  • Fonction : Auteur
Jo A. van Ginderachter
  • Fonction : Auteur
Bernard Malissen
Alain Beschin
  • Fonction : Auteur

Résumé

Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial to mesenchymal transition; however, its role within the immune system is only now being elucidated. We show here that Zeb2 expression is a conserved feature of macrophages. Using Clec4f-cre, Itgax-cre, and Fcgr1-cre mice to target five different macrophage populations, we found that loss of ZEB2 resulted in macrophage disappearance from the tissues, coupled with their subsequent replenishment from bone-marrow precursors in open niches. Mechanistically, we found that ZEB2 functioned to maintain the tissue-specific identities of macrophages. In Kupffer cells, ZEB2 achieved this by regulating expression of the transcription factor LXR alpha, removal of which recapitulated the loss of Kupffer cell identity and disappearance. Thus, ZEB2 expression is required in macrophages to preserve their tissue-specific identities.

Domaines

Immunologie

Dates et versions

hal-02117983 , version 1 (02-05-2019)

Identifiants

Citer

Charlotte L. Scott, Wouter t'Jonck, Liesbet Martens, Helena Todorov, Dorine Sichien, et al.. The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages. Immunity, 2018, 49 (2), pp.312+. ⟨10.1016/j.immuni.2018.07.004⟩. ⟨hal-02117983⟩
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