Article Dans Une Revue Immunological reviews Année : 2018

ILC2 memory: Recollection of previous activation

Itziar Martinez-Gonzalez
  • Fonction : Auteur
Maryam Ghaedi
  • Fonction : Auteur
Catherine A. Steer
  • Fonction : Auteur
Laura Matha
  • Fonction : Auteur
Fumio Takei
  • Fonction : Auteur

Résumé

Immunological memory, traditionally thought to belong to T and B cells, has now been extended to innate lymphocytes, including NK cells and ILC2s, myeloid cells such as macrophages, also termed ``trained immunity'' and more recently to epithelial stem cells. In this review, we discuss the mechanisms underlying memory generation on ILC2s and speculate about their potential role in human allergic diseases, such as asthma. Moreover, we examine the relevance of the spontaneous ILC2 activation in the lung during the neonatal period in order to efficiently respond to stimuli later in life. These ``training'' of neonatal ILC2s may have an impact on the generation of memory ILC2s in the adulthood.

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Dates et versions

hal-02117904 , version 1 (02-05-2019)

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Itziar Martinez-Gonzalez, Maryam Ghaedi, Catherine A. Steer, Laura Matha, Eric Vivier, et al.. ILC2 memory: Recollection of previous activation. Immunological reviews, 2018, 283 (1, SI), pp.41-53. ⟨10.1111/imr.12643⟩. ⟨hal-02117904⟩
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