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Article Dans Une Revue European Polymer Journal Année : 2018

Templated polycondensation of aminopropyltrimethoxysilane on DNA

Résumé

The polycondensation of a silane derivative such asaminopropyltrimethoxysilane (ATMS) in the presence of DNA was investigated in an organicsolvent for the first time. Here, NMR observation showed that the hydrolysis step of ATMSbefore polycondensation was faster when the reaction was carried out in presence of doublestranded DNA (146 bp) in chloroform. In order to test the specificity of this enhancementeffect, the influence of the different components of DNA on ATMS hydrolysis and/orpolycondensation was then investigated using different bases, nucleosides and nucleotides.The results showed that the kinetics of ATMS hydrolysis was affected by the typeofnucleotide units used, the faster hydrolysis reaction rate being observed with moleculescontaining adenosine group, and that in the absence of water the amino group ofdeoxyadenosine units can react with ATMS methoxy groups.
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Dates et versions

hal-02110163 , version 1 (25-04-2019)

Identifiants

Citer

N. Jarroux, M.J. Clément, M. Gervais, S. Moriau, O. Maciejak, et al.. Templated polycondensation of aminopropyltrimethoxysilane on DNA. European Polymer Journal, 2018, 103, pp.95-100. ⟨10.1016/J.EURPOLYMJ.2017.09.045⟩. ⟨hal-02110163⟩
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