Article Dans Une Revue Journal of Bone and Mineral Research Année : 2008

Poly(adp-ribose) Polymerase-1 Regulates Tracp Gene Promoter Activity During RANKL-Induced Osteoclastogenesis

Résumé

The Tracp gene encodes an acid phosphatase strongly upregulated during osteoclastogenesis on RANKL treatment. Using the mouse osteoclastic model RAW264.7, we studied Tracp gene expression, and we identified PARP-1 as a transcriptional repressor negatively regulated by RANKL during osteoclastogenesis.

Dates et versions

hal-02109577 , version 1 (25-04-2019)

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Guillaume E. Beranger, David Momier, Nathalie Rochet, Georges F. Carle, Jean-Claude Scimeca. Poly(adp-ribose) Polymerase-1 Regulates Tracp Gene Promoter Activity During RANKL-Induced Osteoclastogenesis. Journal of Bone and Mineral Research, 2008, 23 (4), pp.564-571. ⟨10.1359/jbmr.071111⟩. ⟨hal-02109577⟩
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