The Many Faces of Amphipathic Helices - Archive ouverte HAL
Article Dans Une Revue (Article De Synthèse) Biomolecules Année : 2018

The Many Faces of Amphipathic Helices

Résumé

Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their structure and by the segregation of hydrophobic and polar residues between two faces of the helix. This segregation allows AHs to adsorb at polar–apolar interfaces such as the lipid surfaces of cellular organelles. Using various examples, we discuss here how variations within this general scheme impart membrane-interacting AHs with different interfacial properties. Among the key parameters are: (i) the size of hydrophobic residues and their density per helical turn; (ii) the nature, the charge, and the distribution of polar residues; and (iii) the length of the AH. Depending on how these parameters are tuned, AHs can deform lipid bilayers, sense membrane curvature, recognize specific lipids, coat lipid droplets, or protect membranes from stress. Via these diverse mechanisms, AHs play important roles in many cellular processes
Fichier principal
Vignette du fichier
main.pdf (1.41 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-02109445 , version 1 (13-11-2024)

Identifiants

Citer

Manuel Giménez-Andrés, Alenka Čopič, Bruno Antonny. The Many Faces of Amphipathic Helices. Biomolecules, 2018, 8 (3), pp.45. ⟨10.3390/biom8030045⟩. ⟨hal-02109445⟩
56 Consultations
2 Téléchargements

Altmetric

Partager

More