Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2019

Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus

Résumé

Lipid disorders have been associated with glomerulopathies, a distinct type of renal pathologies, such as nephrotic syndrome. Global analyses targeting kidney lipids in this pathophysiologic context have been extensively performed, but most often regardless of the architectural and functional complexity of the kidney. The new developments in mass spectrometry imaging technologies have opened a promising field in localized lipidomic studies focused on this organ. In this article, we revisit the main works having employed the Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) technology, and the few reports on the use of TOF-Secondary Ion Mass Spectrometry (TOF-SIMS). We also present a first analysis of mouse kidney cortex sections by cluster TOF-SIMS. The latter represents a good option for high resolution lipid imaging when frozen unfixed histological samples are available. The advantages and drawbacks of this developing field are discussed.
Fichier principal
Vignette du fichier
IntJMolSci_2019_20_1623_Abbas.pdf (621.09 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02107297 , version 1 (05-10-2021)

Identifiants

Citer

Imane Abbas, Manale Noun, David Touboul, Dil Sahali, Alain Brunelle, et al.. Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus. International Journal of Molecular Sciences, 2019, 20 (7), pp.1623. ⟨10.3390/ijms20071623⟩. ⟨hal-02107297⟩
87 Consultations
59 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More