The comparison of chemical abundances in the neutral gas of galaxies to photospheric abundances of old and young stars, ionized gas abundances, and abundances in galactic halos can trace the chemical enrichment of the universe through cosmic times. In particular, our understanding of chemical enrichment through spectroscopic observations of damped Lyman alpha systems (DLAs) relies on corrections for depletion of metals from the gas to the dust phase. These corrections must be determined in the nearby universe, where both gas-phase abundances and photospheric abundances of young stars recently formed out of the interstellar medium can be measured. Multi-object high-resolution (R>50,000) ultraviolet (970-2400 A) and optical (300-600 nm) spectroscopy toward massive stars in local volume galaxies (D < 15 Mpc) covering a wide range of metallicities (a few % solar to solar) and morphological types will provide the abundance and depletion measurements needed to obtain a detailed and comprehensive characterization of the lifecycle of metals in neutral gas and dust in galaxies, thereby observationally addressing important questions about chemical enrichment and galaxy evolution.