Although the evolution of human occupational tasks has been encouraging with a shift from an active lifestyle to a more sedentary way of life, workplaces have also been suggested as a new strategic opportunity to promote physical activity. While there is a growing body of literature regarding the effect of worksite physical activity interventions, there is a need to improve these interventions, their objectives and implementation. This Sounding Board article proposes for the first time a framework regarding the implementation of such interventions within the workplace, suggesting a joint approach combining physical activity and health specialists as well as ergonomists that are experts in human work sciences.