Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Intensive Care Medicine Année : 2019

Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients

Andre Kalil
  • Fonction : Auteur
Matteo Bassetti
  • Fonction : Auteur
  • PersonId : 911731
Ricard Ferrer
  • Fonction : Auteur
Flavia Machado
  • Fonction : Auteur
Malgorzata Mikulska
  • Fonction : Auteur
  • PersonId : 886595
Garyphalia Poulakou
  • Fonction : Auteur
Michel Wolff
  • Fonction : Auteur
  • PersonId : 942231

Résumé

Purpose: Prognosis of solid organ transplant (SOT) recipients has improved, mainly because of better prevention of rejection by immunosuppressive therapies. However, SOT recipients are highly susceptible to conventional and opportunistic infections, which represent a major cause of morbidity, graft dysfunction and mortality. Methods: Narrative review. Results:We cover the current epidemiology and main aspects of infections in SOT recipients including risk factors such as postoperative risks and specific risks for different transplant recipients, key points on anti-infective prophylaxis as well as diagnostic and therapeutic approaches. We provide an up-to-date guide for management of the main syndromes that can be encountered in SOT recipients including acute respiratory failure, sepsis or septic shock, and central nervous system infections as well as bacterial infections with multidrug-resistant strains, invasive fungal diseases, viral infections and less common pathogens that may impact this patient population. Conclusion: We provide state-of the art review of available knowledge of critically ill SOT patients with infections.
Fichier principal
Vignette du fichier
2019 Timsit et al., Diagnostic.pdf (63.13 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02080957 , version 1 (24-06-2020)

Identifiants

Citer

Jean-François Timsit, Romain Sonneville, Andre Kalil, Matteo Bassetti, Ricard Ferrer, et al.. Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients. Intensive Care Medicine, 2019, 45, pp.573-591. ⟨10.1007/s00134-019-05597-y⟩. ⟨hal-02080957⟩
95 Consultations
12 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More