Gd(DTPA-bisamide)alkyl Copolymers: A Hint for the Formation of MRI Contrast Agents with Very High Relaxivity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 1999

Gd(DTPA-bisamide)alkyl Copolymers: A Hint for the Formation of MRI Contrast Agents with Very High Relaxivity

Lothar Helm
  • Fonction : Auteur
Kenneth Kellar
  • Fonction : Auteur
André Merbach
  • Fonction : Auteur

Résumé

The separation of global and local motion for [Gd(DTPA−BA)−(CH2)n]x copolymers (see diagram) shows that, contrary to usual linear polymers, the global rotation can strongly contribute to proton relaxivity. The rate and mechanism of water exchange is not influenced by polymerization. The collective results for these three polymers have important implications for the design of polymeric species with very high proton relaxivities.

Dates et versions

hal-02080907 , version 1 (27-03-2019)

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Citer

Éva Tóth, Lothar Helm, Kenneth Kellar, André Merbach. Gd(DTPA-bisamide)alkyl Copolymers: A Hint for the Formation of MRI Contrast Agents with Very High Relaxivity. Chemistry - A European Journal, 1999, 5 (4), pp.1202-1211. ⟨10.1002/(SICI)1521-3765(19990401)5:4<1202::AID-CHEM1202>3.0.CO;2-Y⟩. ⟨hal-02080907⟩
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