Accelerating water exchange for GdIII chelates by steric compression around the water binding site. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2002

Accelerating water exchange for GdIII chelates by steric compression around the water binding site.

Résumé

The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic GdIII complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA4- by a propylene bridge; in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H2O)]- is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.
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Dates et versions

hal-02080840 , version 1 (27-03-2019)

Identifiants

  • HAL Id : hal-02080840 , version 1
  • PUBMED : 12510271

Citer

Robert Ruloff, Éva Tóth, Rosario Scopelliti, Raphaël Tripier, Henri Handel, et al.. Accelerating water exchange for GdIII chelates by steric compression around the water binding site.. Chemical Communications, 2002, 22, pp.2630-1. ⟨hal-02080840⟩
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