Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C 60 (OH) x and Gd@C 60 [C(COOH 2 )] 10 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the American Chemical Society Année : 2005

Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C 60 (OH) x and Gd@C 60 [C(COOH 2 )] 10

Balaji Sitharaman
  • Fonction : Auteur
Éva Tóth
Robert Bolskar
  • Fonction : Auteur
Lothar Helm
  • Fonction : Auteur
Subashini Asokan
  • Fonction : Auteur
Michael Wong
Lon Wilson
  • Fonction : Auteur
André Merbach
  • Fonction : Auteur

Résumé

A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomena, therefore, their behavior in biological or medical applications. In particular, the relaxivity of gadofullerenes decreases dramatically with phosphate addition. Moreover, real biological fluids present a rather high salt concentration which will have consequences on fullerene aggregation and influence fullerene-based drug delivery.

Dates et versions

hal-02080318 , version 1 (26-03-2019)

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Citer

Sabrina Laus, Balaji Sitharaman, Éva Tóth, Robert Bolskar, Lothar Helm, et al.. Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C 60 (OH) x and Gd@C 60 [C(COOH 2 )] 10. Journal of the American Chemical Society, 2005, 127 (26), pp.9368-9369. ⟨10.1021/ja052388+⟩. ⟨hal-02080318⟩
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