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Article Dans Une Revue Radiochimica Acta Année : 2007

Radiochemical and biological behaviour of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycle

M. Paula Campello
  • Fonction : Auteur
Fernanda Marques
  • Fonction : Auteur
Lurdes Gano
  • Fonction : Auteur
Sara Lacerda
Isabel Santos
  • Fonction : Auteur

Résumé

The novel bis(methylphosphonate) 2,2′-[4,10-bis-(phosphonomemyl)-1,4, 7,10-tetraazacyclododecane-1,7-diyl] diacetic acid, trans-H6DO2A2P, has been synthesized and characterized by multinuclear NMR spectroscopy ( 1H, 13C and 31P). 153Sm and 166Ho complexes with trans-H6DO2A2P have been prepared in high yield using a 1:2 metal to ligand molar ratio at 70°C, pH 8-9. These complexes are hydrophilic, negatively charged and stable in vitro under physiological solutions, up to 48 h. They present a low plasmatic protein binding and some in vitro hydroxyapatite adsorption, mainly for 166Ho-trans-DO2A2P. Both complexes are stable in vivo, have a fast tissue clearance from most organs and a rapid total excretion from whole animal body. Moderate bone uptake was also observed but the accumulated radioactivity rapidly decreases with time.
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hal-02079464 , version 1 (26-03-2019)

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M. Paula Campello, Fernanda Marques, Lurdes Gano, Sara Lacerda, Isabel Santos. Radiochemical and biological behaviour of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycle. Radiochimica Acta, 2007, 95 (6), ⟨10.1524/ract.2007.95.6.329⟩. ⟨hal-02079464⟩
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