This paper deals with a numerical modelling of the Powered Two-Wheelers (PTW) dynamic in order to simulate its behaviour during emergency situations. Firstly, a multibody model of a Honda VFR has been developed. It consists of six bodies and eleven degrees of freedom and takes into account the specificities to simulate hard braking, avoidance and slalom manoeuvres. In parallel, a motorcycle was instrumented to conduct a series of emergency manoeuvres in order to validate the model. The experimental tests have been compared to the simulated model and results give good correlations showing that the model is well adapted to simulate emergency situations.