Gene signature of breast cancer cell lines treated with lycopene - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Pharmacogenomics Année : 2006

Gene signature of breast cancer cell lines treated with lycopene

Résumé

Among the micronutrients studied in relation between nutrition and cancer, lycopene appears to be a breast cancer preventive phytochemical candidate found in raw tomatoes and tomato-derived products. In order to investigate the responsiveness of breast cancer genes to lycopene and to better understand the molecular mechanisms underlying the effects of lycopene, we used an oligonucleotide microarray approach. Human breast cancer cell lines (MCF-7 and MDA-MB-231) and a fibrocystic breast cell line (MCF-10a) were either exposed or not exposed to 10 microM lycopene for 48 h. Microarrays comprising 202 genes were used to identify genes responsive to lycopene supplementation. Hierarchical clustering revealed a cell line-specific lycopene modulation of breast cells. Based on the observed results, lycopene seems to exert regulation on apoptosis, cell cycle and DNA repair mechanisms according to estrogen and retinoic acid receptor cell status.

Domaines

Cancer
Fichier non déposé

Dates et versions

hal-02069077 , version 1 (15-03-2019)

Identifiants

Citer

Nassera Chalabi, Laetitia Delort, Ludovic Le Corre, Samir Satih, Yves-Jean Bignon, et al.. Gene signature of breast cancer cell lines treated with lycopene. Pharmacogenomics, 2006, 7 (5), pp.663-672. ⟨10.2217/14622416.7.5.663⟩. ⟨hal-02069077⟩

Collections

PRES_CLERMONT
15 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More