The impact of digitalization and Industry 4.0 on the ripple effect and disruption risk control analytics in the supply chain (SC) is studied. The research framework combines the results from two isolated areas, i.e., the impact of digitalization on SC management (SCM) and the impact of SCM on the ripple effect control. To the best of our knowledge, this is the first study that connects business, information, engineering and analytics perspectives on digitalization and SC risks. This paper does not pretend to be encyclopedic, but rather analyzes recent literature and case-studies seeking to bring the discussion further with the help of a conceptual framework for researching the relationships between digitaliza-tion and SC disruptions risks. In addition, it emerges with a SC risk analytics framework. It analyzes perspectives and future transformations that can be expected in transition towards cyber-physical SCs. With these two frameworks, this study contributes to the literature by answering the questions of (1) what relations exist between big data analytics, Industry 4.0, additive manufacturing, advanced trace & tracking systems and SC disruption risks; (2) how digitalization can contribute to enhancing ripple effect control; and (3) what digital technology-based extensions can trigger the developments towards SC risk analytics.