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Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2015

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Mathieu Marchivie

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In the aim of identifying new privileged structures, we describe the 5-steps synthesis of cyclic guanidine compounds “tetrahydroisoquinoline-iminoimidazolines” derived from tetrahydroisoquinoline-hydantoin core. In order to evaluate this new minimal structure and the impact of replacing a carbonyle by a guanidine moiety, their affinity towards adenosine receptor A2A was evaluated and compared to those of tetrahydroisoquinoline-hydantoin compounds.
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hal-02060788 , version 1 (08-03-2019)

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Valeria Moas Heloire, Nicolas Renault, Vânia Batalha, Angela Rincon Arias, Mathieu Marchivie, et al.. Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines. European Journal of Medicinal Chemistry, 2015, 106, pp.15-25. ⟨10.1016/j.ejmech.2015.10.030⟩. ⟨hal-02060788⟩
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