High-performance liquid chromatographic analysis of the unusual pathway of oxidation of L-arginine to citrulline and nitric oxide in mammalian cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Chromatography A Année : 1991

High-performance liquid chromatographic analysis of the unusual pathway of oxidation of L-arginine to citrulline and nitric oxide in mammalian cells

Résumé

A very unusual pathway of the oxidation of L-arginine to citrulline and nitric oxide has been discovered recently in cytotoxic macrophages. In an attempt to detect molecules generated through this metabolic pathway, a fast radio high-performance liquid chromatographic method was developed to analyse the whole set of radiolabelled L-arginine-derived metabolites produced by mammalian cells after appropriate induction. A new intermediate, which might be Ng-hydroxy-L-arginine, was found.
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hal-02050600 , version 1 (27-02-2019)

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  • HAL Id : hal-02050600 , version 1

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Benoît Chénais, Alexandre Yapo, Michel Lepoivre, Jean-Pierre Tenu. High-performance liquid chromatographic analysis of the unusual pathway of oxidation of L-arginine to citrulline and nitric oxide in mammalian cells. Journal of Chromatography A, 1991. ⟨hal-02050600⟩
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