Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents - Archive ouverte HAL
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2017

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

Résumé

Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological dysfunctions are involved. Among them, two main types of lesions were discovered and widely studied: the amyloid plaques and the neurofibrillary tangles (NFTs). These two lesions are caused by the dysfunction and the accumulation of two proteins which are, respectively, the beta-amyloid peptide and the tau protein. The process that leads these two proteins to aggregate is complex and is the subject of current studies. After a brief description of the aggregation mechanisms, we will provide an overview of new therapeutic agents targeting the different dysfunctions and toxic species found during aggregation
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Dates et versions

hal-02043725 , version 1 (21-02-2019)

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Marie Jouanne, Sylvain Rault, Anne-Sophie Voisin-Chiret. Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents. European Journal of Medicinal Chemistry, 2017, 139, pp.153-167. ⟨10.1016/j.ejmech.2017.07.070⟩. ⟨hal-02043725⟩
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