Insensitivity of place cells to the value of spatial goals in a two-choice flexible navigation task - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Neuroscience Année : 2019

Insensitivity of place cells to the value of spatial goals in a two-choice flexible navigation task

Résumé

Hippocampal place cells show position-specific activity thought to reflect a self-localization signal. Several reports also point to some form of goal encoding by place cells. We investigated this by asking whether they also encode the value of spatial goals, which is crucial information for optimizing goal-directed navigation. We used a continuous place navigation task in which male rats navigate to one of two (freely chosen) unmarked locations and wait, triggering the release of reward, which is then located and consumed elsewhere. This allows sampling of place fields and dissociates spatial goal from reward consumption. The two goals varied in the amount of reward provided, allowing assessment of whether the rats factored goal value into their navigational choice and of possible neural correlates of this value. Rats successfully learned the task, indicating goal localization, and they preferred higher-value goals, indicating processing of goal value. Replicating previous findings, there was goal-related activity in the out-of-field firing of CA1 place cells, with a ramping-up of firing rate during the waiting period, but no general overrepresentation of goals by place fields, an observation that we extended to CA3 place cells. Importantly, place cells were not modulated by goal value. This suggests that dorsal hippocampal place cells encode space independently of its associated value despite the effect of that value on spatial behavior. Our findings are consistent with a model of place cells in which they provide a spontaneously constructed value-free spatial representation rather than encoding other navigationally relevant but nonspatial information.
Fichier principal
Vignette du fichier
Duvelle et al 2019.pdf (5.63 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02042441 , version 1 (20-02-2019)

Identifiants

Citer

Éléonore Duvelle, Roddy M Grieves, Vincent Hok, Bruno Poucet, Angelo Arleo, et al.. Insensitivity of place cells to the value of spatial goals in a two-choice flexible navigation task. Journal of Neuroscience, 2019, pp.1578-18. ⟨10.1523/jneurosci.1578-18.2018⟩. ⟨hal-02042441⟩
94 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More