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Article Dans Une Revue Tetrahedron Année : 2014

A general synthesis of diversely substituted indazoles and hetero-aromatic derivatives from o-halo-(het)arylaldehydes or -phenones

Résumé

A set of variously substituted indazoles and hetero-aromatic derivatives were synthesized from o-halo-(het)arylaldehydes using a palladium catalyzed amination followed by cyclization. Starting from phenones, this process was extended to give 3-substituted indazoles. Moreover, N-1-substituted-indazoles can be reached by this strategy using an optional selective N-1-alkylation step during the process. This methodology offers a general and easy route for the synthesis of regioselectively substituted indazoles.

Domaines

Chimie organique
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Dates et versions

hal-02011108 , version 1 (07-02-2019)

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Emmanuelle Dubost, Silvia Stiebing, Thibault Ferrary, Thomas Cailly, Frédéric Fabis, et al.. A general synthesis of diversely substituted indazoles and hetero-aromatic derivatives from o-halo-(het)arylaldehydes or -phenones. Tetrahedron, 2014, 70 (44), pp.8413-8418. ⟨10.1016/j.tet.2014.07.092⟩. ⟨hal-02011108⟩
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