We perform an exact-diagonalization study of quasihole excitations for the two-component Halperin (221) state in the lowest Landau level and for several ν=1/3 bosonic fractional Chern insulators in topological flat bands with Chern number |C|=2. Properties including the quasihole size, charge, and braiding statistics are evaluated. For the Halperin (221) model state, we observe isotropic quasiholes with a clear internal structure, and obtain the quasihole charge and statistics matching the theoretical values. Interestingly, we also extract the same quasihole size, charge, and braiding statistics for the continuum model states of |C|=2 fractional Chern insulators, although the latter possess a “color-entangled” nature that does not exist in ordinary two-component Halperin states. We also consider two real lattice models with a band having |C|=2. There we find that a quasihole can exhibit much stronger oscillations of the density profile, while having the same charge and statistics as those in the continuum models.