It is now a rather common approach to perform patient-specific stress analyses of arterial walls using finite-element models reconstructed from gated medical images. However this requires to compute for every Gauss point the deformation gradient between the current configuration and a stressfree reference configuration. It is technically difficult to define such a reference configuration and there is actually no guarantee that a stressfree configuration is physically attainable due to the presence of internal stresses in unloaded soft tissues. An alternative framework was proposed by Bellini et al., 2014. It consists of computing the deformation gradients between the current configuration and a prestressed reference configuration. We present here the first finite-element results based on this concept using the Abaqus software. The reference configuration is set arbitrarily to the in vivo average geometry of the artery, which is obtained from gated medical images and is assumed to be mechanobiologically homeostatic. For every Gauss point, the stress is split additively into the contributions of each individual load-bearing constituent of the tissue, namely elastin, collagen, smooth muscle cells. Each constituent is assigned an independent prestretch in the reference configuration, named the deposition stretch. The outstanding advantage of the present approach is that it simultaneously computes the in situ stresses existing in the reference configuration and predicts the residual stresses that occur after removing the different loadings applied onto the artery (pressure and axial load). As a proof of concept, we applied it on an ideal thick-wall cylinder and showed that the obtained results were consistent with corresponding experimental and analytical results of well-known literature. In addition, we developed a patient-specific model of a human ascending thoracic aneurys-mal aorta and demonstrated the utility in predicting the wall stress distribution in vivo under the effects of physiological pressure. Finally we simulated the whole process preceding traditional in vitro uniaxial tensile testing of arteries, including excision from the body, radial cutting, flattening and subsequent tensile loading, showing how this process may impact the final mechanical properties derived from these in vitro tests.