Regarding “Combination of pediatric and adult formulas yield valid glomerular filtration rate estimates in young adults with a history of pediatric chronic kidney disease”
Résumé
To the editor:
Recently, Ng et al.1
reported that the average of pediatric (serum creatinine–only equation from the Kidney Disease in Children study [CKiDSCr]) and adult (serum creatinine–only equation from the Chronic Kidney Disease Epidemiology Collaboration consortium [CKD-EPISCr]) creatinine-based estimate of the glomerular filtration rate (GFR) yielded valid estimates in young adults. We analyzed the diagnostic performance of this “average” using a data set of 543 patients2
(273 women) aged 18 to 26 years with inulin-measured GFR from 5 to 135 ml/min per 1.73 m2. A linear mixed-effects model was employed to model the set of GFRs and assess the performance of Ng et al.’s equation in terms of bias (mean of difference between estimated and measured GFR), precision (limits of agreement), concordance correlation coefficient, and accuracy (percentage of estimates 30% higher or lower than the measured GFR and root mean square error). The results are shown in Table 1.
