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Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2018

Cobalt-Catalyzed Formation of 2-Pyridylzinc Reagents and Their Subsequent Coupling

Résumé

The preparation of pyridylzinc compounds from the corresponding pyridyl halides using a cobalt catalyst is described. The complex employed features a polydentate N-heterocyclic ligand and allows the reaction to be carried out in the absence of pyridine as co-solvent and also in THF in place of acetonitrile. First cross-coupling attempts are also presented. Satisfactory yields were obtained via a one-pot protocol without the addition of another catalyst.

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hal-01999438 , version 1 (08-12-2023)

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Stephanie Linke, Sofia M Manolikakès, Audrey Auffrant, Corinne Gosmini. Cobalt-Catalyzed Formation of 2-Pyridylzinc Reagents and Their Subsequent Coupling. Synthesis: Journal of Synthetic Organic Chemistry, 2018, 50 (13), pp.2595-2600. ⟨10.1055/s-0037-1609730⟩. ⟨hal-01999438⟩
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