Article Dans Une Revue Journal of Lipid Research Année : 1999

Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects.

Résumé

Decreased lipolytic effect of catecholamines in adipose tissue has repeatedly been demonstrated in obesity and may be a cause of excess accumulation of body fat. However, the mechanisms behind this lipolysis defect are unclear. The role of hormone-sensitive lipase was examined using abdominal subcutaneous adipocytes from 34 obese drug-free and otherwise healthy males or females and 14 non-obese control subjects. The enzyme catalyzes the rate-limiting step of the lipolysis pathway. The maximum lipolytic capacity of fat cells was significantly decreased in obesity when measured using either a non-selective beta-adrenergic receptor agonist (isoprenaline) or a phosphodiesterase resistant cyclic AMP analogue (dibutyryl cyclic AMP). Likewise, enzyme activity, protein expression, and mRNA of hormone-sensitive lipase were significantly decreased in adipocytes of obese subjects. The findings were not influenced by age or gender. The data suggest that a decreased expression of hormone-sensitive lipase in subcutaneous fat cells, which in turn causes decreased enzyme function and impaired lipolytic capacity of adipocytes, is present in obesity. Impaired expression of the hormone-sensitive lipase gene might at least in part explain the enzyme defect.

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Dates et versions

hal-01983641 , version 1 (16-01-2019)

Identifiants

  • HAL Id : hal-01983641 , version 1
  • PUBMED : 10553009

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Valerie Large, Signy Reynisdottir, Dominique Langin, Katrin Fredby, Mia Klannemark, et al.. Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects.. Journal of Lipid Research, 1999, 40 (11), pp.2059-66. ⟨hal-01983641⟩
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