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Article Dans Une Revue Genes and Development Année : 2014

Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans

Résumé

The adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites.
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hal-01976528 , version 1 (26-01-2023)

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Rahul Sharma, Daniel Jost, Jop Kind, Georgina Gómez-Saldivar, Bas van Steensel, et al.. Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans. Genes and Development, 2014, 28 (23), pp.2591-2596. ⟨10.1101/gad.248864.114⟩. ⟨hal-01976528⟩
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