How to improve the sensitivity of coplanar electrodes and micro channel design in electrical impedance flow cytometry: a study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Microfluidics and Nanofluidics Année : 2019

How to improve the sensitivity of coplanar electrodes and micro channel design in electrical impedance flow cytometry: a study

Résumé

This paper describes a comprehensive analysis of the geometrical parameters influencing the sensitivity of a coplanar electrode layout for electrical impedance flow cytometry. The designs presented in this work have been simulated, fabricated, and tested. 3D finite element method was applied to simulate and improve the sensitivity of the coplanar designs for two spacings between electrodes. The proposed model uses conditional expressions to define spatially dependent material properties. The vertical and lateral sensitivities were evaluated for all the designs. The experimental results obtained with polystyrene beads show good agreement with the simulations. Precentering particles with dielectrophoresis allowed to control their position in the microchannel. The optimized designs are envisioned to be used for sizing and characterizing particles from single cells to cell aggregates.
Fichier principal
Vignette du fichier
2019_Cottet_MN.pdf (1.18 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01970310 , version 1 (13-01-2022)

Identifiants

Citer

Jonathan Cottet, Alexandre Kehren, Harald van Lintel, François Buret, Marie Frénéa-Robin, et al.. How to improve the sensitivity of coplanar electrodes and micro channel design in electrical impedance flow cytometry: a study. Microfluidics and Nanofluidics, 2019, 23 (1), ⟨10.1007/s10404-018-2178-6⟩. ⟨hal-01970310⟩
144 Consultations
247 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More