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Article Dans Une Revue Nature Plants Année : 2018

Dynamic and spatial restriction of Polycomb activity by plant histone demethylases

Résumé

Targeted changes in chromatin state at thousands of genes are central to eukaryotic development. RELATIVE OF EARLY FLOWERING 6 (REF6) is a Jumonji-type histone demethylase that counteracts Polycomb repressive complex 2 (PRC2)-mediated gene silencing in plants and was reported to select its binding sites in a direct, sequence-specific manner(1-3). Here we show that REF6 and its two close paralogues determine spatial 'boundaries' of the repressive histone H3K27me3 mark in the genome and control the tissue-specific release from PRC2-mediated gene repression. Targeted mutagenesis revealed that these histone demethylases display pleiotropic, redundant functions in plant development, several of which depend on trans factor-mediated recruitment. Thus, Jumonji-type histone demethylases restrict repressive chromatin domains and contribute to tissue-specific gene activation via complementary targeting mechanisms.
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Dates et versions

hal-01959671 , version 1 (18-12-2018)

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Wenhao Yan, Dijun Chen, Cezary Smaczniak, Julia Engelhorn, Haiyang Liu, et al.. Dynamic and spatial restriction of Polycomb activity by plant histone demethylases. Nature Plants, 2018, 4 (9), pp.681-689. ⟨10.1038/s41477-018-0219-5⟩. ⟨hal-01959671⟩
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