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Article Dans Une Revue Annual Review of Chemical and Biomolecular Engineering Année : 2019

Advances in the Use of Microfluidics to Study Crystallization Fundamentals

Résumé

This review compares droplet-based microfluidic systems used to study crystallization fundamentals in chemistry and biology. An original high-throughput droplet-based microfluidic platform is presented. It uses nL droplets, generates a "chemical library" and directly solubilizes powder, thus economizing both material and time. It is compatible with all solvents without the need for surfactant. Its flexibility permits phase diagram determination and crystallization studies (screening and optimizing experiments), and makes it easy to use for non-specialists in microfluidics. Moreover, it allows concentration measurement via UV spectroscopy and solid characterization via XRD analysis.
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Dates et versions

hal-01959318 , version 1 (18-12-2018)

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Nadine A Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler. Advances in the Use of Microfluidics to Study Crystallization Fundamentals. Annual Review of Chemical and Biomolecular Engineering, 2019, 10 (1), pp.59-83. ⟨10.1146/annurev-chembioeng-060718-030312⟩. ⟨hal-01959318⟩
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