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Conference Papers Year : 2018

Distinct Characteristics Of Human Ventricular Fibrillation In Its Initial Phase

Josselin Duchateau
  • Function : Author
Stéphane Puyo
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Hubert Cochet
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Marianna Meo
  • Function : Author
Grégoire Massoullié
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Anna Lam
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Felix Bourier
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Nicolas Klotz
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Philippe Ritter
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Pierre Jaïs
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Richard D. Walton
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Rémi Dubois
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Background: Ventricular fibrillation (VF) progresses rapidly from an initial organized stage to chaotic fibrillation. The characteristics of initial drivers, that may be critical for therapeutic interventions, have not been investigated. Objective: To characterize the initial drivers of Human VF Methods: We evaluated 51 patients (44±10 years) who survived VF associated with ischemic heart disease in 15, cardiomyopathy in 14 and Brugada syndrome in 22. VF was mapped by intracardiac and body-surface recordings to analyze spatial organization, cycle lengths (CL), and drivers at the origin of wavefronts. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented signals (≥70ms). Results: We mapped 69 episodes of spontaneous (n=12) or induced (n=57) VF for 17±10 s. The VF CL decreased from 208±28 to 172±25 ms (p<0.001) with the fastest acceleration consistently occurring in the initial 5 s. Initial organized VF, lasting 4.3 ± 1s, showed recurring wavefront sequences arising from distinct driver areas of focal or reentrant activity. These drivers were specifically associated with the abnormal ventricular substrate: in Brugada syndrome, they originated from individual locations in the right ventricle whereas in ischemic heart disease or cardiomyopathy, they originated dominantly from scar borderline in the left ventricle. In contrast, during the disorganized VF phase, the drivers were disseminated in both ventricles producing widespread unstable reentries without specific link with underlying ventricular substrate. In 32 patients, the driver areas were ablated using radiofrequency energy resulting in arrhythmia-free outcome in 27 patients at 20±19 months follow- up. Conclusion: The early phase in which human VF appears electrocardiographically well-organized, is unique as it is associated with a limited number of drivers distinctly related to underlying abnormal substrate. These primary drivers will then rapidly accelerate and disseminate to establish disorganized fibrillation.
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Dates and versions

hal-01954669 , version 1 (13-12-2018)


  • HAL Id : hal-01954669 , version 1


Michel Haïssaguerre, Josselin Duchateau, Ghassen Cheniti, Stéphane Puyo, Arnaud Denis, et al.. Distinct Characteristics Of Human Ventricular Fibrillation In Its Initial Phase. Heart Rhythm Meeting - 39th Annual Scientific Sessions, May 2018, Boston, United States. ⟨hal-01954669⟩
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