A special repertoire of $\alpha$:$\beta$ T cells in neonatal mice. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue EMBO Journal Année : 1991

A special repertoire of $\alpha$:$\beta$ T cells in neonatal mice.

Résumé

According to several functional criteria, the mature thymocytes of neonatal and adult mice are distinctly different. We wondered whether these differences in function might have a structural correlate: do neonates have a distinct repertoire of $\alpha$:$\beta$ T cells? In this study, we have exploited the power of polymerase chain reaction technology to generate large numbers of T cell receptor sequences from sorted thymocyte populations from newborn and adult mice. The newborn-derived sequences show very few N nucleotide additions, usually the major source of diversity in T cell receptors. Most interestingly, the paucity of N insertions appears to be exaggerated by selection events that operate during T cell differentiation in the thymus. The significance of these results is largely: (i) that they parallel recent findings on the B cell repertoire in neonates, raising questions about the reactivities specified by such a special repertoire; and (ii) that they suggest a means to 'tag' T cells exported perinatally, allowing one to test the premise that autoreactive T cells derive preferentially from the newborn repertoire.
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Dates et versions

hal-01949121 , version 1 (09-12-2018)

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  • HAL Id : hal-01949121 , version 1
  • PUBMED : 1834457

Citer

M. Bogue, Serge M. Candéias, C. Benoist, D. Mathis. A special repertoire of $\alpha$:$\beta$ T cells in neonatal mice.. EMBO Journal, 1991, 10 (12), pp.3647-3654. ⟨hal-01949121⟩

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