IL-7 activates alpha4beta1 integrin in murine thymocytes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 1997

IL-7 activates alpha4beta1 integrin in murine thymocytes.

S Kitazawa
  • Fonction : Auteur
M Muegge
  • Fonction : Auteur
R Badolato
  • Fonction : Auteur
W Fogler
  • Fonction : Auteur
D Ferris
  • Fonction : Auteur
C Lee
  • Fonction : Auteur
S Smith
  • Fonction : Auteur
J Oppenheim
  • Fonction : Auteur
S Durum
  • Fonction : Auteur

Résumé

IL-7, a cytokine produced by thymic epithelium, was shown to induce adhesion of murine thymocytes to gelatin-coated membranes. A major binding component of gelatin was identified as fibronectin. IL-7-induced adhesion was observed for all of the major thymocyte subsets, including double-negative, double-positive, and single-positive cells, and specific IL-7R were verified on each subset. Fibronectin binding was mediated via alpha4beta1 integrin (VLA-4), which is expressed at high levels on thymocytes. VLA-4 surface expression was not increased following IL-7 treatment, but was shown to undergo rapid tyrosine phosphorylation on the beta1 subunit. This tyrosine phosphorylation was blocked by genistein, which also blocked IL-7-induced adhesion. IL-7 was detected on the extracellular matrix of the thymus, suggesting that it could promote matrix association through an integrin pathway.
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Dates et versions

hal-01949103 , version 1 (09-12-2018)

Identifiants

  • HAL Id : hal-01949103 , version 1
  • PUBMED : 9278314

Citer

S Kitazawa, M Muegge, R Badolato, J. Wang, W Fogler, et al.. IL-7 activates alpha4beta1 integrin in murine thymocytes.. Journal of Immunology, 1997, 159 (5), pp.2259-64. ⟨hal-01949103⟩
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