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Article Dans Une Revue Vibrational Spectroscopy Année : 2017

Vibrational spectroscopic study on polycationic phosphorus dendrimers

Résumé

Three generations of phosphorus dendrimers with pyrrolidine end groups were synthesized for use in biology and medicine. Neutral samples are soluble in organic solvents but after protonation these dendrimers become water-soluble and can be used for biological experiments. The FTIR and FT Raman spectra of three generations of dendrimers Gi constructed from the cyclotriphosphazene core, repeating units OC6H4CHNN(CH3)P(S)< and aminoethylpyrrolidine end groups NH(CH2)2C4NH9 were registered. Analysis of the IR spectra of Gi shows that the NH groups form a hydrogen bond with chlorine atoms. The calculation of the vibrational spectra was performed for the optimal structure of the first generation dendrimer in the framework of the DFT method. The first-generation dendrimer molecule has flat, repeating units and a plane of symmetry passing through the cyclotriphosphazene core. Calculation of the distribution of the potential energy made it possible to assign the bands in the experimental vibrational spectra. Amine groups show NH stretching bands at 3397 and 3200cm−1, NH+ stretching bands occur at 2645 and 2546cm−1 in the IR spectrum of G1. The stretching vibrations of the NH+ group are significantly shifted to low frequencies due to the formation of a hydrogen bond with the chlorine atom. The line at 1577cm−1 in the Raman spectrum is characteristic of repeating units.
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Dates et versions

hal-01945633 , version 1 (05-12-2018)

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V. L. Furer, A. E. Vandyukov, V. Tripathi, Jean Pierre Majoral, A.-M. Caminade, et al.. Vibrational spectroscopic study on polycationic phosphorus dendrimers. Vibrational Spectroscopy, 2017, 93 (Supplement C), pp.65-77. ⟨10.1016/j.vibspec.2017.10.004⟩. ⟨hal-01945633⟩
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