Atmospheric Pressure Multijet Plasma Source for PlasmaMedicine Applications
Résumé
Single plasma jets have allowed significant advances in in vivo or directly on human experiments
(e.g. [1], [2]). The results are particularly promising, but, ultimately, they couldbe limited in the
future due to the fact that the treatment times are rather long due to the very small surface area
treated by the produced plasma. There is a real challenge to develop sources that allow treatment
over larger areas while remaining practical and at a reasonable cost. To this end, there are
already flexible or rigid surface DBDs but they require an extremely small distance between the
reactor and the treated tissues, which limits their use in many situations (particularly when the
treated surfaces exhibit large variations in the surface morphology leading to points of
attachment of streamers and therefore to a very inhomogeneous treatment). "Ideal" sources are
therefore sources with the flexibility of a jet and treatment surfaces comparable to large DBDs. It
is in this spirit that we have developed a new generation of applicators based on a single Plasma
Gun system and able to generate a multitude of jets (from tens up to few hundreds) from
theprimary plasma jet, as shown in Fig. 1.
Fig. 1: Multijet plasma source from single Plasma Gun
Before proceeding to in vivo treatments, we qualified the sourcesthrough in vitro experiments of
decontamination on colonies grown on agar plates in traditional Petri dishes, to check the
equivalence of each of the jets generated, as well as on colonies grown onvery large agarsurfaces
scanned with our system,to check large surface treatment feasibility. The results are extremely
encouraging and demonstrate the effectiveness of the multijet system, which allows both the
processing of large-scale targets as well as the reductionof the processing times that otherwise
can be prohibitive with single-jet systems.We will present experimental results obtained on the
generation of different types of multijets, as well as results obtained with one multijet plasma
source on the decontamination of multi-resistant bacterial colonies grown from hospital inpatient
samples.
Acknowledgements
This work was supported by the CNRS PEPS project ACUMULTIPLAS and the ITMO Cancer
in the frame of the Plan Cancer, project N°17CP086-00.
References
[1] L. Brulé et al, Plos One 7, 0052653 (2012)
[2] H R Metelmannet al, CPM, 9, 6(2018)