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Poster De Conférence Année : 2018

On the untapped potential of the CO molecule in plasma medicine and agriculture

Résumé

In plasma medicine and agriculture reactive species produced by non-thermal plasma sources must play an important role. Many studies have been devoted on the effects of reactive species such as O, O2 1Δg, OH, N, NO and NO2 species just to name a few. So far, the CO molecule has been overlooked. Carbon monoxide (CO) is well known for its toxic effects at high doses. The effects of CO can be quantified via the percentage of carboxyhemoglobin (COHb) it forms in the blood. The percentage of COHb in blood strongly depends on, not only the percentage of CO in air, but also on the exposure time. CO is however also naturally produced at cellular level, mostly via the catabolism of heme. At low doses, CO has therapeutic properties. Experimental studies found several positive effects of CO such as anti-inflammatory, vasodilatory and anti-apoptotic effects. It has also an influence on plants and promote the seed germination and increases the roots formation [1]. In this contribution, we will shortly review the reactivity of CO at the molecular level and its effects as a signaling molecule. It will be shown that CO triggers and competes with several cellular receptors which are sensitive to the NO molecule as well. Many studies have demonstrated over the years that plasmas are able to produced CO from the dissociation of CO2 over a wide range of concentrations. Using glow discharges, dielectric barrier discharges, nanosecond pulsed discharges or microwave plasmas, CO can be produced from ppm range to several tens %. Plasmas are flexible sources allowing in situ production of CO and alleviate the risks related to its storage. Additionally, plasmas produce other components of biological relevance such as electric fields, heat, ultraviolet radiation, O, NO, NO2 and many other reactive species. Synergic effects may therefore occur for the treatment of certain afflictions. For instance, it has been demonstrated that high doses of NO have a pro-inflammatory action [2] while exogenous CO can down regulates its effects [3]. Plasmas with CO2 admixtures as a source of CO seem then promising in applications such as wound healing and seed germination. References [1] E. Carbone and C. Douat, Plasma Medicine, 8(1):93–120 (2018). [2] Guzik TJ, Korbut R, Adamek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 2003;54(4):469–87. [3] Ingi T, Cheng J, Ronnett G V. Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System. Neuron. 1996;16(4):835–42.

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Plasmas
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Dates et versions

hal-01943082 , version 1 (03-12-2018)

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  • HAL Id : hal-01943082 , version 1

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Claire Douat, Jean-Michel Pouvesle, Eric Robert, Emile Carbone. On the untapped potential of the CO molecule in plasma medicine and agriculture. ICPM7, Jun 2018, Philadelphia, United States. ⟨hal-01943082⟩
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