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Article Dans Une Revue Polymers Année : 2017

Smart poly(imidazoyl-l-lysine): Synthesis and reversible helix-to-coil transition at neutral pH

Résumé

Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes.

Dates et versions

hal-01940590 , version 1 (30-11-2018)

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Estefanía Piedra-Arroni, Fatma Makni, Laura Severac, Jean-Luc Stigliani, G. Pratviel, et al.. Smart poly(imidazoyl-l-lysine): Synthesis and reversible helix-to-coil transition at neutral pH. Polymers, 2017, 9 (7), pp.276. ⟨10.3390/polym9070276⟩. ⟨hal-01940590⟩
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