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Article Dans Une Revue Acta Dermato-Venereologica Année : 2015

Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma

Stéphane Dalle
Sophie Dalac
Jean-Philippe Lacour

Résumé

The prognostic value of the sentinel lymph node in Merkel cell carcinoma (MCC) has been examined previously in heterogeneous retrospective studies. The current retrospective study included a homogeneous population of patients with a localized MCC, all staged with sentinel lymph node biopsy. Factors associated with 3-year progression-free survival were analysed using logistic regression. The sentinel lymph node was positive in 32% of patients. The recurrence rate was 26.9%. In first analyses (n = 108), gender (p = 0.0115) and the presence of immunosuppression (p = 0.0494) were the only significant independent factors. In further analyses (n = 80), excluding patients treated with regional radiotherapy, sentinel lymph node status was the only significant prognostic factor (p = 0.0281). Immunosuppression and positive sentinel lymph node are associated with a worse prognosis in patients with MCC. Nodal irradiation impacts on the prognostic value of the sentinel lymph node status.

Domaines

Dermatologie
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Dates et versions

hal-01934939 , version 1 (26-11-2018)

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Thomas Jouary, Emeline Kubica, Stéphane Dalle, Cecile Pages, Anne-Benedicte Duval-Modeste, et al.. Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma. Acta Dermato-Venereologica, 2015, 95 (7), pp.835-40. ⟨10.2340/00015555-2099⟩. ⟨hal-01934939⟩
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