Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BioMed Research International Année : 2014

Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies

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A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn's disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed.
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hal-01931428 , version 1 (27-05-2020)

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Allison Agus, Sébastien Massier, Arlette Darfeuille-Michaud, Elisabeth Billard, Nicolas Barnich. Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies. BioMed Research International , 2014, 2014, pp.1 - 16. ⟨10.1155/2014/567929⟩. ⟨hal-01931428⟩
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