Reduced Graphene Oxide Embedded Polymeric Nanofiber Mats: An ‘On-Demand’ Photothermally-Triggered Antibiotic Release Platform
Résumé
The steady increase in antimicrobial resistance in different 16 pathogens requires the development of alternative treatment strategies 17 next to the oral delivery of antibiotics. A photothermally activated 18 platform based on reduced graphene oxide (rGO)-embedded polymeric 19 nanofiber mats for on-demand release of antibiotics upon irradiation in 20 the near-infrared is fabricated. Cross-linked hydrophilic nanofibers, 21 obtained by electrospinning a mixture of poly(acrylic acid) (PAA) and 22 rGO, show excellent stability in aqueous media. Importantly, these PAA@ 23 rGO nanofiber mats exhibit controlled photothermal heating upon 24 irradiation at 980 nm. Nanofiber mats are efficiently loaded with 25 antibiotics through simple immersion into corresponding antibiotics 26 solutions. Whereas passive diffusion based release at room temperature is 27 extremely low, photothermal activation results in increased release within 28 few minutes, with release rates tunable through power density of the 29 applied irradiation. The large difference over passive and active release, as well as the controlled turn-on of release allows 30 regulation of the dosage of the antibiotics, as evidenced by the inhibition of planktonic bacteria growth. Treatment of superficial 31 skin infections with the antibiotic-loaded nanofiber mats show efficient wound healing of the infected site. Facile fabrication and 32 implementation of these photothermally active nanofiber mats makes this novel platform adaptable for on-demand delivery of 33 various therapeutic agents. 34
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