Phosphorus-based dendrimer ABP treats neuroinflammation by promoting IL-10-producing CD4+ T Cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomacromolecules Année : 2015

Phosphorus-based dendrimer ABP treats neuroinflammation by promoting IL-10-producing CD4+ T Cells

Résumé

Dendrimers are polyfunctional nano-objects of perfectly defined structure that can provide innovative alternatives for the treatment of chronic inflammatory diseases, including multiple sclerosis (MS). To investigate the efficiency of a recently described amino-bis(methylene phosphonate)-capped ABP dendrimer as a potential drug candidate for MS, we used the classical mouse model of MOG35–55-induced experimental autoimmune encephalomyelitis (EAE). Our study provides evidence that the ABP dendrimer prevents the development of EAE and inhibits the progression of established disease with a comparable therapeutic benefit as the approved treatment Fingolimod. We also show that the ABP dendrimer redirects the pathogenic myelin-specific CD4+ T cell response toward IL-10 production.
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Dates et versions

hal-01923202 , version 1 (15-11-2018)

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Myriam Hayder, Marjorie Varilh, Cédric-Olivier Turrin, Abdelhadi Saoudi, A.-M. Caminade, et al.. Phosphorus-based dendrimer ABP treats neuroinflammation by promoting IL-10-producing CD4+ T Cells. Biomacromolecules, 2015, 16 (11), pp.3425-3433. ⟨10.1021/acs.biomac.5b00643⟩. ⟨hal-01923202⟩
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