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Article Dans Une Revue Current Opinion in Structural Biology Année : 2015

From local to global changes in proteins: a network view

Claire Lesieur

Résumé

To fulfill the biological activities in living organisms, proteins are endowed with dynamics, robustness and adaptability. The three properties co-exist because they allow global changes in structure to arise from local perturbations (dynamics). Robustness refers to the ability of the protein to incur such changes without suffering loss of function; adaptability is the emergence of a new biological activity. Since loss of function may jeopardize the survival of the organism and lead to disease, adaptability may occur through the combination of two local perturbations that together rescue the initial function. The review highlights the relevancy of computational network analysis to understand how a local change produces global changes.
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hal-01921161 , version 1 (13-11-2018)

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Laurent Vuillon, Claire Lesieur. From local to global changes in proteins: a network view. Current Opinion in Structural Biology, 2015, 31, pp.1 - 8. ⟨10.1016/j.sbi.2015.02.015⟩. ⟨hal-01921161⟩
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