Real study: Re-treatment evaluated on visual acuity for Lucentis® in neovascular AMD [Real study : retraitement par Lucentis® dans la DMLA neovasculaire évalué sur l'acuité visuelle] - Archive ouverte HAL Access content directly
Journal Articles Journal Français d'Ophtalmologie Year : 2018

Real study: Re-treatment evaluated on visual acuity for Lucentis® in neovascular AMD [Real study : retraitement par Lucentis® dans la DMLA neovasculaire évalué sur l'acuité visuelle]

D. Bellocq
  • Function : Author
F. de Bats
  • Function : Author
Muriel Rabilloud

Abstract

Purpose: To assess the value of a monthly injection of Lucentis® until stable visual acuity (VA) is obtained for three consecutive months without exudation in patients with neovascular age macular degeneration (AMD). Methods: Prospective, single-center, non-controlled trial including naïve AMD patients with neovascularization. An assessment of VA and a spectral domain optical coherence tomography (SD-OCT) were performed at baseline and every month. Monthly injections of Lucentis® were performed over three months. The monthly injections were then continued until three consecutive stable VA results were obtained with no signs of exudation. Results: Fifteen out of the 21 patients included were anatomically good responders. A mean gain of +14Le (9) was obtained up to the point at which there was no exudation. There was no additional gain from this point until 3 consecutive stable VA results were obtained. During the PRN phase, an additional mean gain of +3.2Le (7.7) was obtained. Conclusion: This initial VA-guided regimen with ranibizumab might prevent the slight decrease in VA observed during the first year of PRN studies. © 2018 Elsevier Masson SAS

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hal-01916267 , version 1 (08-11-2018)

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D. Bellocq, F. de Bats, Muriel Rabilloud, L. Kodjikian. Real study: Re-treatment evaluated on visual acuity for Lucentis® in neovascular AMD [Real study : retraitement par Lucentis® dans la DMLA neovasculaire évalué sur l'acuité visuelle]. Journal Français d'Ophtalmologie, 2018, 41 (5), pp.397-401. ⟨10.1016/j.jfo.2017.10.014⟩. ⟨hal-01916267⟩
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