Topical ivermectin improves allergic skin inflammation
Résumé
BACKGROUND: Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti-inflammatory properties. METHODS: Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunological assays. RESULTS: Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen-specific T cells, as well as the production of inflammatory cytokines. While IVM had no major impact on the functions of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytokine production following polyclonal and antigen-specific stimulation. CONCLUSION: Altogether, our results show that IVM is endowed with topical anti-inflammatory properties that could have important applications for the treatment of T-cell-mediated skin inflammatory diseases.
Mots clés
Administration
Topical
Allergens
Animals
Antigens
Dermatophagoides
atopic dermatitis
Cell Line
Cytokines
Dendritic Cells
Dermatitis
Atopic
Disease Models
Animal
Enzyme-Linked Immunospot Assay
Fragile X Mental Retardation Protein
Humans
Inflammation Mediators
Ivermectin
Lymphocyte Activation
Macrophages
Mice
Knockout
Receptors
Purinergic P2X4
skin inflammatory diseases
T-cell immunity
T-Lymphocyte Subsets
topical treatment