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Journal Articles Médecine et Maladies Infectieuses Year : 2018

Tigecycline-based prolonged salvage therapy in patients presenting with complex bone and joint infection

Abstract

OBJECTIVES: To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS: Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS: Thirty-six patients (age 58.2\textpm17.8 years; 21 men) were included. The most frequently isolated bacteria were Enterobacteriaceae and staphylococci. Tigecycline (50mg BID, mainly in combination (69.4%), mean duration of 58 days) was indicated for multidrug resistance (90.6%) and/or previous antibiotic intolerance (36.1%), and/or as second- or third-line therapy (69.4%). Six patients (16.7%) experienced early treatment discontinuation for adverse event (4 severe vomiting, 1 pancreatitis, 1 asymptomatic lipase increase). Clinical success was observed in 23 of 30 assessable patients who completed the tigecycline therapy (mean follow-up: 54.1\textpm57.7 weeks). CONCLUSION: Prolonged tigecycline-based therapy could be an alternative in patients presenting with BJI requiring salvage therapy, especially if multidrug-resistant Enterobacteriaceae and/or staphylococci are involved.
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Dates and versions

hal-01911105 , version 1 (02-11-2018)

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J. Wach, A. Dinh, H. Dutronc, O. R. Sipahi, A. Candevir, et al.. Tigecycline-based prolonged salvage therapy in patients presenting with complex bone and joint infection. Médecine et Maladies Infectieuses, 2018, 48 (1), pp.53-57. ⟨10.1016/j.medmal.2017.09.001⟩. ⟨hal-01911105⟩
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